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• The P-II study assesses the safety and tolerability of casdozokitug (10mg/kg, IV, Q3W) + atezolizumab (1200 mg) & bevacizumab (15mg/kg) in patients (n=30) with treatment-naïve unresectable locally advanced/metastatic hepatocellular carcinoma (uHCC)
• The results, as of Nov 9, 2023, showed an ORR of 38% (n=29), with 11 durable objective responses (3 CRs and 8 PRs), mPFS was 8.1mos. & DCR was 58.6%, based on RECIST v1.1 criteria. Another analysis showed an ORR of 43% (n=28), with 12 durable objective responses (3 CRs and 9 PRs), mPFS was not attained & DCR was 60.7%, based on mRECIST
• Casdozokitug is a FIC human anti-IL-27 antibody that targets the activity of the immunosuppressive cytokine

Ref: Coherus | Image: Coherus

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